Agencies-Gaza post
Omega-3 improves the efficacy of anti-cancer immunotherapy
Omega-3 improves the efficacy of anti-cancer immunotherapy, a new mouse study suggested that omega-3 fatty acids can help immunotherapy and other cancer treatments work more effectively.
Immunotherapy, which stimulates the body’s immune system to attack cancer is one of the most important treatments that has revolutionized cancer treatment.
However, it does not work for all patients, a research assistant at Boston’s Rhea Medical Center said.
it added that dietary interventions can be powerful tools because they are relatively simple and inexpensive to implement.
According to research, omega-3 fatty acids can help reduce the risk of cancer, whereas omega-6 fatty acids can cause cancer.
Omega-3 fatty acids can be found in fish, nuts, and seeds, whereas omega-6 fatty acids can be found in meat, eggs, and other foods.
Kelly and author researcher “Deepak Panigrahi” wanted to find out how diets supplemented with these fatty acids affected immunotherapy and anti-inflammatory therapy by inhibiting the soluble epoxide hydroxide enzyme.
Immunotherapy has been approved by regulators and is being used clinically, whereas anti-inflammatory therapy is still in the early stages of development.
The researchers discovered that dietary omega-3 fatty acid supplements inhibited tumor growth in mice treated with immunotherapy or enzyme inhibitors.
In contrast, mice fed a high omega-6 diet and given immunotherapy experienced rapid tumor growth in certain types of tumors.
The results showed that in mice given a high omega-3 diet and cancer treatments, tumor growth was reduced by 67 percent compared to mice given no treatment and a normal diet, indicating a possible synergistic activity against the tumor, which means that the combined effect may be greater than the sum of its parts.
We demonstrated for the first time that the combination of immunotherapy and anti-inflammatory therapy (sEHi) was most effective when the mice were fed a diet rich in antioxidants.
Researchers are now conducting additional studies to determine the mechanism of action of the potential synergistic antitumor activity produced by Omega-3 supplementation.
These studies are being conducted on human cancer tissue and cells, human immune cells, and animal models in order to help translate them to cancer patients.
Kelly and colleagues’ new findings could represent a new therapeutic approach that needs to be tested in humans.
The researchers will present their new findings at the American Society for Investigative Pathology’s annual meeting during the Experimental Biology Meeting (EB) 2022, which will be held in Philadelphia from April 2 to 5.
SOURCE: HERE
